Building on the appeal and power of the drama a number of specific health promotion activities have taken place. These include 1-800 numbers for information on the health conditions raised in the show; Internet addresses for more detailed information; and a local news segment [in every local market within the news programnes that immediately follow ER] called "Following E.R.", which picks up on the health theme in the show [e.g., accidents] with local stories [e.g., the work of accident prevention groups].

Major health issues, HIV/AIDS, Youth Health, rape, cancer, prevention methods, personal attitudes, many others.

According to the Kaiser Family Foundation (KFF), ER has a well-researched plot and script that provide accurate information about health issues and are an effective media to reach target communities. ER reaches people through positive and negative role models.